The Devonshire, which opened in 2007, is one of three pubs the company owns in London which also include the Narrow in Limehouse and the Warrington in Maida Vale.
A spokeswoman for GRH confirmed that the Devonshire has closed. "The Devonshire pub has not been meeting our expectations for awhile and we have taken the decision to close it while we consider future plans," she said.
"There are a number of options and a final decision will be made in due course."
The closure of the pub comes six months after the departure of Mark Sargeant, who left GRH last November and was instrumental in the group's roll out of its three London pubs.
GRH's most recent accounts revealed that the company made a loss of more than £4m in the year to August 2008.